Desmocollin 1 is abundantly expressed in atherosclerosis and impairs high-density lipoprotein biogenesis
Authors' conclusion
The binding of apoA-I to two functionally opposing PM microdomains, ABCA1 and DSC1 domains, suggests that HDL biogenesis and PM cholesterol levels may be regulated by the relative abundance of the two domains
Study context
- Population
- Cholesterol-laden cells/macrophages and human atherosclerotic lesions
- Outcome
- Novel cellular factors regulating HDL biogenesis
Main finding
As reported in the abstract
- ApoA-I binds cholesterol-rich, DSC1-containing plasma membrane (PM) microdomains
- DSC1 binds apoA-I and prevents its interaction with ABCA1-created microdomains for high-density lipoprotein (HDL) formation
- Silencing DSC1 or DSC1 blocking antibodies increase apoA-I access to ABCA1 microdomains and enhance HDL biogenesis
- DSC1 abundantly expressed in macrophages and human atherosclerotic lesions
Original publication
Desmocollin 1 is abundantly expressed in atherosclerosis and impairs high-density lipoprotein biogenesis. Eur Heart J. Published 29 June 2017. doi:10.
Summarised from the published abstract; every number is checked against it