Heart failure & cardiomyopathiesCohort study
Determinants and associations of health-related quality of life with mortality in acute and chronic heart failure: findings from the ESC heart failure (HF) III Registry
- Registry
Authors' conclusion
HRQoL provides important clinical information and may provide additional insight into patients’ health status and disease progression beyond conventional clinical measures.
Study context
- Population
- Patients hospitalized with acute HF or outpatient HF visitsacute HF: 38.6%
- Participants
- 10,130 patients
- Outcome
- Demographic, clinical, behavioural, and treatment factors associated with HRQoL in HF, association between HRQoL and mortality, and changes in HRQoL over 1-year
- Follow-up
- 1-year
Main finding
Baseline HRQoL and mortality · 1 year
Higher risk of death
9%
As reported in the abstract
- Baseline health-related quality of life (HRQoL) in acute HF vs outpatients
- worse baseline HRQoL in acute HF
- Factors strongly associated with lower HRQoL in acute and outpatient HF
- older age, female sex, eGFR ≤29, NYHA class III/IV, and dyspnoea at rest
- Improved HRQoL at 1 year
- 45% of patients
- Patient subgroups with more common HRQoL improvements at 1 year
- acute HF, mildly reduced ejection fraction, and women
- HRQoL at 1 year with ACEi/ARBs/ARNIs
- modest improvement
Observational data: associations, not effects.
Original publication
Determinants and associations of health-related quality of life with mortality in acute and chronic heart failure: findings from the ESC HF III Registry. Eur J Heart Fail. Published 1 October 2026. doi:10.1093/ejhf/xuag236
Summarised from the published abstract; every number is checked against it