Heart failure & cardiomyopathies
Determinants of Guideline-Directed Medical Therapy Implementation During Heart Failure Hospitalization
Authors' conclusion
Suboptimal implementation of GDMT during HF hospitalization is widespread and is associated with a worse outcome. Black patients and patients experiencing homelessness were less likely to have GDMT optimized.
Study context
- Population
- Adults with new-onset or previously diagnosed HFrEF in unplanned heart failure (HF) hospitalization, 2017–2018152 [38.9%] new-onset HFrEF
- Participants
- 391 adults
- Outcome
- Discharge mOMT score (GDMT implementation)
- Follow-up
- Discharge
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Perfect or near-perfect discharge mOMT score
Patients with perfect or near-perfect discharge modified optimal medical therapy (mOMT) score
49
12.5%
Observational data: associations, not effects.
Further findings
Socioeconomic factors and discharge mOMT score
- Black patients and those experiencing homelessness had significantly lower discharge mOMT scores
Composite of 1-year all-cause mortality and 1-year HF readmission, by discharge mOMT score
- Reduction in composite endpoint per 0.1-increase in mOMT score
- 9.2%
- Higher discharge mOMT score associated with lower rate of composite endpoint events, particularly in new-onset HFrEF
Original publication
Determinants of Guideline-Directed Medical Therapy Implementation During Heart Failure Hospitalization. JACC Adv. Published 14 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →