Determinants of medication adherence in patients with acute coronary syndrome: a secondary analysis of a randomised clinical trial
Authors' conclusion
Sociodemographic and clinical factors may influence medication adherence. Greater awareness, discussion and monitoring of these factors during patient follow-up may help improve medication adherence.
Study context
- Population
- Patients with acute coronary syndrome (ACS) in the TEXTMEDS trialparticipants with complete adherence data, of 1424 patients in the trial, mean age 58.5±10.7 years, 1095 (79.4%) men
- Participants
- 1,379 patients
- Comparison
- Effect of sociodemographic and clinical factors on medication adherence
- Primary endpoint
- Self-reported medication adherence (>80% of indicated medications taken, >24/30 days in the preceding 1 month, for all five classes of guideline-recommended cardioprotective medications)
- Follow-up
- Both 6 and 12 months
Methodological detailssingle-blind randomised clinical trial (TEXTMEDS), 18 hospitals across Australia, Logistic regression analysis and the Least Absolute Shrinkage and Selection Operator regularisation technique
- Single-blind randomised clinical trial (TEXTMEDS)
- 18 hospitals across Australia
- Logistic regression analysis and the Least Absolute Shrinkage and Selection Operator regularisation technique
Primary result
As reported in the abstract
Odds ratio (95% CI)
Greater number of total medications takenassociated with adherence
1.33(1.25–1.42)
Attending a cardiac rehabilitation programmeassociated with adherence
1.47(1.17–1.86)
Female sexassociated with lower likelihood of medication adherence
0.67(0.50–0.90)
Physical disabilityassociated with lower likelihood of medication adherence
0.43(0.23–0.77)
Original publication
Determinants of medication adherence in patients with acute coronary syndrome: a secondary analysis of a randomised clinical trial. Heart. Published 16 January 2025. doi:10.
Summarised from the published abstract; every number is checked against it