Heart failure & cardiomyopathiesDiagnostic or prognostic study
Development and Validation of a Noninvasive Model of Mixed Venous Oxygen Saturation in Heart Failure
- Development and Validation of a Noninvasive Model
Authors' conclusion
The CMR iSvO2, measured from simple T2 maps of left and right ventricular blood pool, allows accurate estimation of the invasive SvO2. In a real-world heart failure registry, iSvO2 is an independent predictor of mortality and heart failure hospitalization.
Study context
- Population
- Patients with heart failure; discovery cohort undergoing cardiovascular magnetic resonance (CMR) T2 mapping and invasive right heart catheterization; validation cohort with recently diagnosed heart failurediscovery cohort N = 30 · validation cohort 628
- Participants
- 30 vs 628
- Comparison
- iSvO2 against invasive mixed venous oxygen saturation
- discovery cohortn = 30
- validation cohortn = 628
- Outcome
- all-cause mortality or heart failure hospitalization
- Follow-up
- Median 3 years [IQR: 1.5-4.8]
Performance
As reported in the abstract
Hazard ratio
0.66 10% change in iSvO2
95% CI 0.54–0.81
P < 0.001
iSvO2
HR 0.66 10% change in iSvO2 (95% CI 0.54–0.81); P < 0.001
Further findings
Correlation of RV blood pool T2/LV blood pool T2 ratio with invasive mixed venous oxygen saturation
- R
- 0.82; 95% CI: 0.66-0.91; P < 0.001
- equation
- iSvO2 = 95·(RV-T2BP/LV-T2BP)
- discovery cohort
Original publication
Development and Validation of a Noninvasive Model of Mixed Venous Oxygen Saturation in Heart Failure. JACC Adv. doi:10.1016/j.jacadv.2025.102484
Summarised from the published abstract; every number is checked against it