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Acute cardiac care & resuscitation

Device-Related Adverse Events and Outcomes in Patients With Temporary Mechanical Circulatory Support Placed at Referral Centers Versus Cardiogenic Shock Hub Centers: An Observational Analysis

Circ Heart FailPublished

  • Observational Analysis
  • single center
+1 more
  • single center
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Authors' conclusion

Initial tMCS placement for CS at an RRC with transfer to an HC is associated with a higher DRAE prevalence and worse outcomes than initial tMCS placement at a CS HC. The higher mortality in RRC-implanted patients may be due to greater CS severity.

Study context

Population
Patients with temporary mechanical circulatory support (temporary mechanical support (tMCS)) for cardiogenic shock (CS), August 2021 to August 2024, stratified by location of initial tMCS device placement77% HC-implanted, 23% RRC-implanted
Participants
398 patients
Exposure
tMCS placement for CS at an RRC before transfer to an HC compared with initial tMCS device placement at an HC

Main finding

As reported in the abstract

Unadjusted in-hospital mortality
Each group vs HC-implantedOdds ratio (95% CI)P value
RRC-implantedunadjusted
2.52(1.52–4.18)
P < 0.001
In-hospital mortality after adjustment for CS severity and cardiac arrest — RRC-implanted
1.72(0.95–3.12)
P = 0.07

Observational data: associations, not effects.

Further findings

Outcomeodds ratio (95% CI)P value
Unfavorable outcomes (death before discharge, heart transplant, or durable left ventricular assist device) — RRC-implanted vs HC-implanted · unadjusted2.55 (1.52–4.27)P < 0.001
Unfavorable outcomes (death before discharge, heart transplant, or durable left ventricular assist device) — RRC-implanted vs HC-implanted · after adjustment for CS severity and cardiac arrest1.60 (0.87–2.92)P = 0.13

Baseline characteristics

RRC-implanted patients more commonly experienced cardiac arrest and had more advanced CS

Safety

DRAE prevalence

any DRAE

bleeding

hemolysis

vascular injury

DRAE rate · numerically higher among RRC-implanted

DRAE rate — Overall DRAE rate
0.33 events/patient-week
  • DRAE prevalence: P <0.05 for all

Original publication

Device-Related Adverse Events and Outcomes in Patients With Temporary Mechanical Circulatory Support Placed at Referral Centers Versus Cardiogenic Shock Hub Centers: An Observational Analysis. Circ Heart Fail. Published 13 April 2026. doi:10.1161/circheartfailure.125.013742
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Summarised from the published abstract; every number is checked against it