Cardio-oncology & otherCohort study
Device-Removal, Reinfection, and Mortality After Staphylococcus aureus Bacteremia in Patients With Cardiac Implantable Electronic Devices
- nationwide register-based cohort study
- sex and age-matched non-CIED controls with Staphylococcus aureus bacteremia (SAB)
- landmark analysis at the time of hospital discharge
Authors' conclusion
The Danish CIED carriers had slightly higher 30-day all-cause mortality after SAB compared to matched controls. Only a minor selected proportion underwent device removal after SAB diagnosis and, after initial survival, these patients had lower 180-days reinfection rates and mortality compared to patients with retained devices.
Study context
- Population
- Patients with SAB after cardiac implantable electronic device (CIED) implantation in Denmark between 2000 and 2020patients with CIED and SAB, plus 9,080 matched controls · patients with CIED and SAB 1,816 · matched controls 9,080
- Participants
- 1,816 patients
- Exposure
- patients with CIED vs controls
- patients with CIEDn = 1,816
- controlsn = 9,080reference
Main finding
All-cause mortality · 30 days
Adjusted hazard ratio
1.11
95% CI 1.02–1.22
P = 0.019
By group
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | patients with CIED | controls | device removal | retained CIEDs |
|---|---|---|---|---|
| Device removal · within 30 days | 15.8% | Not reported in the abstract | Not reported in the abstract | Not reported in the abstract |
| Cumulative incidence of SAB reinfection and all-cause mortality (landmark analysis) · 180 days | ||||
| reinfection | Not reported in the abstract | Not reported in the abstract | 2.5% | 5.5% |
| mortality | Not reported in the abstract | Not reported in the abstract | 7.8% | 31.2% |
Cumulative incidence of SAB reinfection and all-cause mortality (landmark analysis) · 180 days
- significantly lower in patients undergoing device removal compared to those with retained CIEDs
Baseline characteristics by removal status
- Patients who underwent CIED removal were younger and had less comorbidity compared to those with retained CIEDs
Original publication
Summarised from the published abstract; every number is checked against it