Valvular & structural heart diseaseCohort study
Diabetes and elevated plasma glucose in heart valve calcification and disease: the Copenhagen General Population Study
- Prospective cohort study
- general population
- multivariable adjusted
Authors' conclusion
Diabetes and elevated plasma glucose were associated with risk of aortic and mitral valve calcification and aortic valve stenosis. The risk of aortic valve stenosis was partly explained by elevated plasma triglycerides, hypertension, and BMI.
Study context
- Population
- Copenhagen General Population Study; cardiac CT subset for valve calcification12,006 with cardiac CT
- Participants
- 110,291 participants
- Exposure
- Diabetes vs no diabetes; plasma glucose ≥6.6 vs ≤5.1 mmol/L
- Outcome
- Aortic and mitral valve calcification (CT) and aortic valve stenosis (health registers)
Main finding
As reported in the abstract
Estimate
Diabetes vs No diabetesaortic valve calcification, multivariable adjusted
OR 1.67(95% CI 1.34–2.08)
Diabetes vs No diabetesmitral valve calcification, multivariable adjusted
OR 1.89(CI 1.48–2.40)
Diabetes vs No diabetesaortic valve stenosis
HR 1.71(CI 1.44–2.03)
Glucose ≥6.6 mmol/L vs Glucose ≤5.1 mmol/Laortic valve calcification, multivariable adjusted
OR 1.27(CI 1.07–1.52)
Glucose ≥6.6 mmol/L vs Glucose ≤5.1 mmol/Lmitral valve calcification, multivariable adjusted
OR 1.44(CI 1.18–1.77)
Glucose ≥6.6 mmol/L vs Glucose ≤5.1 mmol/Laortic valve stenosis
HR 1.33(CI 1.12–1.57)
Observational data: associations, not effects.
Further findings
Valve calcification prevalence (cardiac CT subset)
- Aortic valve calcification
- 3018 (25%)
- Mitral valve calcification
- 1521 (13%)
Proportion of diabetes–aortic valve stenosis association explained (mediation)
- Plasma TG
- 4.8% (95% CI: 0.5-11%)
- Hypertension
- 19% (14-28%)
- Body mass index (BMI)
- 27% (18-43%)
Original publication
Diabetes and elevated plasma glucose in heart valve calcification and disease: the Copenhagen General Population Study. Eur J Prev Cardiol. Published 26 February 2025. doi:10.1093/eurjpc/zwaf106
Summarised from the published abstract; every number is checked against it