Cardiometabolic & kidneyResearch article
Diabetes Mellitus, Cumulative Glucose Exposure, and Incident Cardiovascular Disease Risk
- sequential propensity-score-matched sample
- Cox proportional hazards regression models
Authors' conclusion
Diabetes by age 40 years was associated with higher subsequent CVD risk beyond established risk factors, with CVD risk increasing as cumulative glucose exposure rose.
Study context
- Population
- CARDIA (Coronary Artery Risk Development in Young Adults) study participants, assessed at age 40 yearspropensity-score-matched participants, of 4,931 individuals
- Participants
- 766 participants
- Comparison
- diabetes vs nondiabetes
Main finding
Incident CVD · median 22-year follow-up after age 40 years
Hazard ratio
2.13
95% CI 1.33–3.41
P = 0.002
diabetes vs nondiabetes
HR 2.13 (95% CI 1.33–3.41); P = 0.002
As reported in the abstract
- incident cardiovascular disease (CVD) events
- 103
Further findings
Excess CVD rate associated with diabetes vs other risk factors
- Among matched participants, the excess CVD rate associated with diabetes was greater than the rate difference associated with other cardiovascular risk factors commonly elevated in diabetes
Original publication
Diabetes Mellitus, Cumulative Glucose Exposure, and Incident Cardiovascular Disease Risk. JACC Adv. Published 7 August 2026. doi:10.1016/j.jacadv.2026.103087
Summarised from the published abstract; every number is checked against it