Arrhythmias & electrophysiology
Diagnosis to Ablation in Persistent Atrial Fibrillation (AF): Any Time Can Be a Good Time to Ablate
Primary result · AF recurrenceResult — go to the resultHazard ratio 1.607 95% CI 1.005–2.570Authors' conclusion
In a cohort of patients with persistent AF undergoing ablation in a prospective trial with standardized entry criteria and intensive electrocardiogram monitoring, those with shorter DAT had lower rates of AF recurrence. However, differences were modest, and all quartiles demonstrated very low AF burden and improvements in quality of life.
Study context
- Population
- Patients with persistent AF undergoing catheter ablation (PVI ± posterior wall isolation) in the CAPLA trialmedian diagnosis-to-ablation time (DAT) 28 months
- Participants
- 334 patients
- Comparison
- DAT quartiles
- Q1n = 84reference
- Q2n = 85
- Q3n = 84
- Q4n = 81
- Primary endpoint
- AF recurrence (after 3-month blanking period)
- Follow-up
- 12 months
Methodological detailsmulticentre
- Multicentre
Primary result
AF recurrence
Hazard ratio
1.607
95% CI 1.005–2.570
P = 0.048
By group
Q4vs Q1
HR 1.607 (95% CI 1.005–2.570); P = 0.048
As reported in the abstract
Further findings
| Outcome | Q1 | Q2 | Q3 | Q4 | P value |
|---|---|---|---|---|---|
| AF burdenQ4 vs Q1 · median | 0% (IQR 0%–0.47%) | — not stated in the abstract | — not stated in the abstract | 0.33% (IQR 0%–4.6%) | P = 0.002 |
| Quality of life change (AFEQT) | Δ28.8 ± 24 | Δ24.4 ± 23.4 | Δ21.7 ± 26.6 | Δ24.6 ± 21.4 |
— not stated in the abstract
- Quality of life change (AFEQT) — Improved markedly in all quartiles
- P = 0.331
Original publication
Diagnosis to Ablation in Persistent AF: Any Time Can Be a Good Time to Ablate. JACC Clin Electrophysiol. Published July 2024. doi:10.
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