Heart failure & cardiomyopathies
Diagnostic Accuracy of Natriuretic Peptide Screening for Left Ventricular Systolic Dysfunction in the Community: Systematic Review and Meta-Analysis
Authors' conclusion
Our findings suggest that in high-risk community populations NP screening may accurately detect LVSD, potentially providing an important opportunity for diagnosis and early intervention.
Study context
- Population
- Screened general and high-risk (≥1 CV risk factor) community adult populations
- Participants
- 26,565 participants · 24 studies
- Comparison
- N-terminal prohormone brain natriuretic peptide (NT-proBNP) vs BNP screening for left ventricular systolic dysfunction (LVSD)
- Outcome
- Pooled diagnostic accuracy of natriuretic peptide (NP) screening to detect LVSD in high-risk populations
Methodological detailshierarchical summary ROC curves
- Hierarchical summary ROC curves
Pooled result
As reported in the abstract
LVSD detection, high-risk populations
| Group | Sensitivity | Specificity |
|---|---|---|
| NT-proBNP | 0.87 (95% CI 0.73-0.94) | 0.84 (95% CI 0.55-0.96) |
| BNP | 0.75 (95% CI 0.65-0.83) | 0.78 (95% CI 0.72-0.84) |
Sensitivity
NT-proBNP0.87 (95% CI 0.73-0.94)
BNP0.75 (95% CI 0.65-0.83)
Specificity
NT-proBNP0.84 (95% CI 0.55-0.96)
BNP0.78 (95% CI 0.72-0.84)
Further pooled results
| Outcome | NT-proBNP | BNP |
|---|---|---|
| Optimal cut-off, high-risk and general populations combined | ||
| Optimal cut-off | 311 pg/mL | 49 pg/mL |
| Sensitivity | 0.74 (95% CI 0.53-0.88) | 0.68 (95% CI 0.45-0.85) |
| Specificity | 0.85 (95% CI 0.68-0.93) | 0.81 (0.67-0.90) |
- Optimal cut-off, high-risk and general populations combined: optimal thresholds not calculable for high-risk populations alone
Original publication
Diagnostic Accuracy of Natriuretic Peptide Screening for Left Ventricular Systolic Dysfunction in the Community: Systematic Review and Meta-Analysis. ESC Heart Fail. Published 13 February 2023. doi:10.
Summarised from the published abstract; every number is checked against it