Heart failure & cardiomyopathies
Diagnostic Performance and Interpreter Experience of 1-Hour Versus 3-Hour 99m Tc-HMDP Cardiac Amyloid Radionuclide Imaging: A Prospective, Blinded Comparison
Authors' conclusion
In a prospective, blinded comparison of 1-hour versus 3-hour HMDP-CARI, diagnostic performance and interpreter experience were similar, with readers requesting CT fusion more frequently at 1 hour to optimize myocardial-to-blood pool discrimination.
Study context
- Population
- Consecutive patients with suspected transthyretin amyloid cardiomyopathyeach patient imaged at both timepoints
- Participants
- 114 patients
- Comparison
- 1-hour vs 3-hour 99mTc-HMDP cardiac amyloid radionuclide imaging
- Outcome
- Diagnostic performance and interpreter experience (overall interpretation, Perugini grade, interpretation difficulty, interpreter confidence, need for CT fusion)
Methodological detailsprospective, blinded, within-patient comparison
- Prospective
- Blinded
- Within-patient comparison
Performance
As reported in the abstract
Cases requiring arbitration
P = 0.049
Interpreter confidence
P = 0.317
CT fusion needed
P < 0.001
- 1-hour vs 3-hour: P < 0.001 — contrast resolution inferior at 1 hour (lower 3D score)
- Interinterpreter agreement high at both time points
- κ≥0.81
- Overall interpretation concordant between time points
- 111/114 (97%)
- Perugini grades concordant between time points
- 106/114 (93%)
- Negative at 1 hour but equivocal at 3 hours, all clinically ruled out for ATTR cardiomyopathy
- 3 (3%)
Original publication
Diagnostic Performance and Interpreter Experience of 1-Hour Versus 3-Hour 99m Tc-HMDP Cardiac Amyloid Radionuclide Imaging: A Prospective, Blinded Comparison. Circ Cardiovasc Imaging. Published 8 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →