Diagnostic performance of exercise stress tests for detection of epicardial and microvascular coronary artery disease: the UZ Clear study
Authors' conclusion
In patients with evidence of ischaemia, an invasive functional assessment accounting for the epicardial and microvascular compartments led to an improvement in the diagnostic performance of exercise tests, driven by a significant FDR reduction.
Study context
- Population
- Patients with intermediate pretest probability of coronary artery disease (CAD) and positive exercise stress tests referred for invasive angiography
- Participants
- 107 patients · 137 vessels
- Comparison
- Exercise stress test false discovery rate (FDR) with quantitative coronary angiography (QCA) vs fractional flow reserve (FFR) vs FFR+index of microvascular resistance (IMR) as reference
- Outcome
- False discovery rate (FDR) of exercise stress tests with FFR and IMR as references
Methodological detailsprospective, single-arm, multicentre
- Prospective
- Single-arm
- Multicentre
Performance
FDR of exercise stress tests
FDR reduction
25%
P = 0.006
By group
As reported in the abstract
Further findings
Baseline invasive findings
- Mean diameter stenosis
- 37.2±27.5%
- Mean FFR
- 0.84±0.10
- Mean coronary flow reserve
- 2.74±2.07
- Mean IMR
- 20.3±11.9
- Obstructive CAD present
- 39.3%
- Coronary microvascular dysfunction (CMD) detected
- 20.6%
Original publication
Diagnostic performance of exercise stress tests for detection of epicardial and microvascular coronary artery disease: the UZ Clear study. EuroIntervention. Published 6 February 2023. doi:10.
Summarised from the published abstract; every number is checked against it