Valvular & structural heart diseaseDiagnostic or prognostic study
Diagnostic Value of Aortic Valve Calcification Levels in the Assessment of Low-Gradient Aortic Stenosis
- Diagnostic accuracy study
Authors' conclusion
Multi-slice computed tomography-derived AVC scores showed poor discrimination between grades of AS severity using DSE and cannot replace DSE in the diagnostic work-up of low-gradient severe AS.
Study context
- Population
- Patients with low-gradient aortic stenosis (AS) (aortic valve area <1 cm², peak aortic valve velocity <4.0 m/s)
- Participants
- 214 patients
- Comparison
- Aortic valve calcification (AVC) score vs echocardiography and dobutamine stress echocardiography (DSE) for AS severity grading
- Outcome
- Diagnostic value of AVC for AS severity grading as determined by echocardiography and DSE
Performance
As reported in the abstract
Severe AS
| Test or model | Sensitivity | Specificity | PPV | NPV | AUC (men) | AUC (women) |
|---|---|---|---|---|---|---|
| AVC score | 44.3% | 56.5% | 50.0% | 50.8% | 0.508 | 0.524 |
Further findings
High AVC score by AS grade
- High AVC score by AS grade: Severe AS 106 (49.5%); moderate AS 108 (50.5%)
Original publication
Diagnostic Value of Aortic Valve Calcification Levels in the Assessment of Low-Gradient Aortic Stenosis. JACC Cardiovasc Imaging. Published 22 May 2024. doi:10.1016/j.jcmg.2024.03.014
Summarised from the published abstract; every number is checked against it