Coronary disease & ACSCohort study
Diagnostic Yield and Safety of Invasive Coronary Function Testing After Radial Versus Femoral Access
- Dutch multicenter collaboration on coronary function testing (CFT)
- registry
Authors' conclusion
Primary radial access with routine administration of calcium channel blockers was not associated with a lower diagnostic yield in CFT than primary femoral access. Procedural safety was comparable.
Study context
- Population
- Patients who underwent CFT between December 2020 and July 2025patients included · primary radial access 1,436 · primary femoral access 380 · conversion from radial to femoral access 69
- Participants
- 1,885 patients
- Exposure
- CFT by radial access with intraarterial calcium channel blockers compared with CFT by femoral access
- primary radial accessn = 1,436
- primary femoral accessn = 380
- conversion groupn = 69
Main finding
As reported in the abstract
Total diagnostic yield of coronary vasomotor dysfunction
Total diagnostic yield
78.5%
Observational data: associations, not effects.
Further findings
| Outcome | primary radial access | primary femoral access | conversion group | P value |
|---|---|---|---|---|
| Prevalence of coronary vasomotor dysfunction · no significant difference | 79.2% | 75.3% | Not reported in the abstract | P = 0.1 |
| Total diagnostic yield, without conversion vs conversion group · no difference | Not reported in the abstract | Not reported in the abstract | 82.6% | P = 0.4 |
| Spasm · more prevalent in the conversion group | Not reported in the abstract | Not reported in the abstract | 79.4% | P = 0.04 |
- Total diagnostic yield, without conversion vs conversion group: group without conversion 78.4%
- Spasm: group without conversion 67.7%
Safety
CFT complication rates
- No differences in CFT complication rates between groups
Original publication
Diagnostic Yield and Safety of Invasive Coronary Function Testing After Radial Versus Femoral Access. Circ Cardiovasc Interv. Published 29 March 2026. doi:10.1161/circinterventions.125.016450
Summarised from the published abstract; every number is checked against it