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Acute cardiac care & resuscitationCohort study

Diastolic blood pressure and end-tidal carbon dioxide during adult ICU cardiopulmonary resuscitation: association with return of spontaneous circulation

ResuscitationPublished

  • prospective observational study
  • adult medical-surgical ICU
  • 9 months
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Authors' conclusion

In adult ICU cardiac arrest events with simultaneous arterial pressure and capnographic monitoring, both DBP and EtCO2 were associated with ROSC. DBP showed numerically higher discrimination than EtCO2, although this was not statistically significant for mean values across the CPR episode. Last recorded pre-outcome values should be interpreted only as peri-outcome associations and not as real-time predictors or treatment targets. DBP and EtCO2 should be viewed as complementary physiologic markers during CPR.

Study context

Population
Adult patients with an indwelling arterial catheter and mainstream capnography at the time of cardiac arrest in an adult medical-surgical ICUcardiac arrest events from 63 patients
Participants
68 patients
Exposure
ROSC vs without ROSC
  • ROSCn = 29
Outcome
ROSC

Main finding

As reported in the abstract

ROSC achieved

29 events (42.6%)

Observational data: associations, not effects.

Further findings

Mean, mmHg

OutcomeROSCwithout ROSCmean difference (mmHg) (95% CI)P value
Mean DBP across the CPR episode · higher with ROSC39 (SD 18)24 (SD 10)15 (8–23)P < 0.001
Mean EtCO2 across the CPR episode · higher with ROSC19 (SD 5)15 (SD 6)4 (1–6)P = 0.010

Discrimination for ROSC, mean values (diastolic blood pressure (DBP) vs EtCO2)

AUC DBP
0.78
AUC EtCO2
0.69
DeLong p
P = 0.30
  • numerically higher for DBP, not statistically significant

Discrimination for ROSC, last recorded pre-outcome values (secondary peri-outcome analysis)

AUC DBP
0.96
AUC EtCO2
0.85
DeLong p
P = 0.04
  • time point identifiable only after ROSC or termination of resuscitation

Original publication

Diastolic blood pressure and end-tidal carbon dioxide during adult ICU cardiopulmonary resuscitation: association with return of spontaneous circulation. Resuscitation. Published 22 June 2026. doi:10.1016/j.resuscitation.2026.111177
Read the original article ↗PubMedCite RIS · BibTeX

Summarised from the published abstract; every number is checked against it