Prevention & lipidsCohort study
Dietary Acculturation Is Associated With Altered Gut Microbiome, Circulating Metabolites, and Cardiovascular Disease Risk in US Hispanics and Latinos: Results From HCHS/SOL
- Prospective cohort study
Authors' conclusion
Among US Hispanic and Latino adults, greater dietary acculturation was associated with elevated CVD risk, possibly through alterations in gut microbiota and related metabolites.
Study context
- Population
- US Hispanic and Latino adults (HCHS/SOL)211 cardiovascular disease (CVD) cases
- Participants
- 14,172 participants
- Exposure
- Higher vs lower dietary acculturation score
- Outcome
- Incident CVD
- Follow-up
- ≈7 years
Main finding
As reported in the abstract
Incident CVD per SD of dietary acculturation score
Hazard ratio
1.33
95% CI 1.13–1.57
Dietary acculturation score (per SD)
HR 1.33 (95% CI 1.13–1.57)
Per SD, as printed
Observational data: associations, not effects.
Further findings
Gut microbial species associated with dietary acculturation · visit 2, 2014 to 2017
- Microbial species associated
- 69
- Enriched species
- 17
- Depleted species, mainly fiber-utilizing Clostridia and Prevotella
- 52
- n=2349
Metabolites associated with both diet acculturation-related gut microbiota and incident CVD
- Metabolites, mainly fatty acid and glycerophospholipid metabolism
- 25
Proxy association of diet acculturation-related microbiome with CVD risk
- Positive relationship (r)
- 0.70, P<0.001
Original publication
Dietary Acculturation Is Associated With Altered Gut Microbiome, Circulating Metabolites, and Cardiovascular Disease Risk in US Hispanics and Latinos: Results From HCHS/SOL. Circulation. Published 19 June 2024. doi:10.1161/circulationaha.124.069824
Summarised from the published abstract; every number is checked against it