Arrhythmias & electrophysiology
Differences in coagulation responses to vascular injury between uninterrupted dabigatran and apixaban: A clinical prospective randomized study
Authors' conclusion
Unlike uninterrupted apixaban, uninterrupted dabigatran does not inhibit thrombin generation in response to vascular injury.
Study context
- Population
- Patients scheduled for catheter ablation for AF
- Participants
- 42 patients
- Comparison
- Uninterrupted dabigatran vs uninterrupted apixaban
- Primary endpoint
- Prothrombin fragment 1+2 level
- Follow-up
- After vascular puncture
Methodological detailsprospective, parallel-group
- Prospective
- Parallel-group
Primary result
As reported in the abstract
Prothrombin fragment 1+2
P < 0.001
Further findings
Antithrombin and protein C after vascular puncture
- Antithrombin decreased with dabigatran; protein C and antithrombin decreased with apixaban
Original publication
Differences in coagulation responses to vascular injury between uninterrupted dabigatran and apixaban: A clinical prospective randomized study. Heart Rhythm. Published 15 July 2024. doi:10.
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