Arrhythmias & electrophysiologyCohort study
Different underlying aetiologies in patients presenting with ventricular tachycardia fulfilling task force criteria for arrhythmogenic right ventricular cardiomyopathy: initial suspicion based on the 12-lead electrocardiogram
- Retrospective cohort study
- registry-based
Authors' conclusion
In P/LP- patients presenting with VT and fulfilling TFC, an aRVi-ECG should raise suspicion for a different underlying aetiology. In P/LP+ patients, an aRVi-ECG may identify those with poor outcome.
Study context
- Population
- Patients fulfilling task force criteria (TFC) for definite arrhythmogenic right ventricular cardiomyopathy (ARVC), presenting with sustained ventricular tachycardia (VT), with genetic testing (Netherlands Heart Institute Arrhythmogenic Cardiomyopathy (NHI-ACM) registry)
- Participants
- 159 patients
- Exposure
- P/LP+ vs P/LP- patients; aRVi-ECG vs no aRVi-ECG
- P/LP+n = 122
- P/LP-n = 37
- Outcome
- aRVi-ECG (PR prolongation ≥220 ms and/or maximum R'-wave surface area in V1-V3 ≥1.65 mm²) on the first ECG after VT
Main finding
As reported in the abstract
aRVi-ECG
P = 0.038
- Total patients with aRVi-ECG
- 19
Observational data: associations, not effects.
Further findings
- Classified as 'different aetiology' (P/LP-)
- 46% · 17 of 37
- Classified as 'different aetiology' (P/LP-) — Including all P/LP- patients with an aRVi-ECG
- 8
- p.Arg14del phospholamban variant and death, P/LP+ with vs without aRVi-ECG: P/LP+ with aRVi-ECG p.Arg14del 46% · Died 64%
- p.Arg14del phospholamban variant and death, P/LP+ with vs without aRVi-ECG: P/LP+ without aRVi-ECG p.Arg14del 15 · Died 19%
- p.Arg14del phospholamban variant and death, P/LP+ with vs without aRVi-ECG: both P < 0.01
Original publication
Different underlying aetiologies in patients presenting with ventricular tachycardia fulfilling task force criteria for arrhythmogenic right ventricular cardiomyopathy: initial suspicion based on the 12-lead electrocardiogram. Europace. Published 20 August 2025. doi:10.1093/europace/euaf136
Summarised from the published abstract; every number is checked against it