Prevention & lipidsRandomised controlled trial
Digitally Enabled Quality Improvement Intervention and Low-density Lipoprotein Cholesterol (LDL-C) Control in Atherosclerotic Cardiovascular Disease
- Cluster randomised controlled trial
- pragmatic
- 2-arm
- 28 clusters (outpatient clinics), Brazil
Authors' conclusion
In this pragmatic cluster randomized clinical trial, a digitally enabled, multifaceted strategy produced modest LDL-C reduction and increased treatment intensification among patients with ASCVD.
Study context
- Population
- Adults (≥18 years) with established atherosclerotic cardiovascular disease (ASCVD) in outpatient clinics in Brazil, enrolled November 2023–December 202428 clusters
- Participants
- 1,465 adults
- Comparison
- Digitally enabled quality improvement (QI) intervention vs routine practice
- Interventionn = 714
- Controln = 751reference
- Primary endpoint
- Mean LDL-C level
- Follow-up
- 6 months
Primary result
As reported in the abstract
Mean LDL-C
Secondary outcomes
| Outcome | Intervention | Control | OR (95% CI) | |
|---|---|---|---|---|
| LDL-C <50 mg/dL | 23.5% | 13.4% | 1.86 (1.30–2.65) | |
| ≥50% LDL-C reduction | 18.6% | 13.4% | 1.76 (1.27–2.43) | |
| 0.20.5125Odds ratio (log scale) |
Intensive and combination lipid-lowering therapy prescription
- Significantly higher with intervention
Major CV events
- No significant differences
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Digitally Enabled Quality Improvement Intervention and LDL-C Control in Atherosclerotic Cardiovascular Disease. JAMA Cardiol. Published 1 September 2026. doi:10.1001/jamacardio.2026.2510
Summarised from the published abstract; every number is checked against it