Directly measured vs. calculated remnant cholesterol identifies additional overlooked individuals in the general population at higher risk of myocardial infarction
Authors' conclusion
Directly measured vs. calculated remnant cholesterol identifies 5% overlooked individuals in the general population with cholesterol-rich, triglyceride-poor remnants and 1.8-fold increased risk of MI.
Study context
- Population
- General population, Copenhagen General Population Study
- Participants
- 16,207 participants
- Exposure
- Directly measured vs calculated remnant cholesterol
- Outcome
- Ischaemic heart disease (IHD) and myocardial infarction (MI)
- Follow-up
- 14 years
Main finding
As reported in the abstract
IHD and MI, ≥95th vs <40th percentile
Each group vs <40th percentileHazard ratio (95% CI)
Direct ≥95th percentileIHD
1.75(1.42–2.15)
Calculated ≥95th percentileIHD
1.76(1.42–2.17)
Direct ≥95th percentileMI
2.05(1.50–2.80)
Calculated ≥95th percentileMI
1.93(1.40–2.66)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| IHD and MI by ≥80th percentile category (reference: both <80th percentile, 75%)Only direct ≥80th (5%) vs Both <80th · IHD | 1.42 (1.15–1.75) | |
| IHD and MI by ≥80th percentile category (reference: both <80th percentile, 75%)Only direct ≥80th (5%) vs Both <80th · MI | 1.83 (1.35–2.47) | |
| IHD and MI by ≥80th percentile category (reference: both <80th percentile, 75%)Only calculated ≥80th (5%) vs Both <80th · IHD | 1.14 (0.91–1.44) | |
| IHD and MI by ≥80th percentile category (reference: both <80th percentile, 75%)Only calculated ≥80th (5%) vs Both <80th · MI | 1.14 (0.80–1.62) | |
| IHD and MI by ≥80th percentile category (reference: both <80th percentile, 75%)Both ≥80th (15%) vs Both <80th · IHD | 1.48 (1.30–1.68) | |
| IHD and MI by ≥80th percentile category (reference: both <80th percentile, 75%)Both ≥80th (15%) vs Both <80th · MI | 1.67 (1.38–2.01) | |
| 0.512Hazard ratio (log scale) |
| Outcome | High direct | High calculated |
|---|---|---|
| Lipid profile in high direct vs high calculated remnant cholesterol | ||
| Direct remnant cholesterol | 1.9 mmol/L | 1.5 mmol/L |
| Plasma TG | 2.0 mmol/L | 2.7 mmol/L |
| Plasma apolipoprotein B | 132 mg/dL | 142 mg/dL |
Original publication
Directly measured vs. calculated remnant cholesterol identifies additional overlooked individuals in the general population at higher risk of myocardial infarction. Eur Heart J. Published 23 May 2021. doi:10.
Summarised from the published abstract; every number is checked against it