Cohort study
Discordance between left atrial pressure and risk scores in assessment of heart failure with preserved ejection fraction in patients with atrial fibrillation undergoing catheter ablation
- Cohort study
Authors' conclusion
Over one-third of catheter ablation patients had elevated LAP.
Study context
- Population
- Symptomatic atrial fibrillation (AF) patients undergoing catheter ablation (median age 65 years, 41% female)
- Participants
- 336 patients
- Exposure
- Elevated left atrial pressure (LAP) vs non-elevated LAP
- Elevated LAPn = 125
- Outcome
- Prevalence of and factors associated with elevated LAP; concordance between elevated LAP and HFpEF risk scores
Main finding
As reported in the abstract
Elevated LAP (mean LAP ≥ 15 mmHg)
Elevated LAP
37%
125 of 125
- Higher body mass index (BMI) associated with elevated LAP
- OR 1.21 (1.11-1.31) (95% CI)
- Lower LA reservoir strain associated with elevated LAP
- OR 0.97 (0.94-0.99) (95% CI)
Observational data: associations, not effects.
Further findings
AF recurrence · 12 months
P = 0.775
Repeat ablations · 12 months
P = 0.230
High heart failure with preserved ejection fraction (HFpEF) probability (H2FPEF ≥ 6 and/or HFA-PEFF ≥ 5)
- High HFpEF probability among 204 eligible patients
- 36%
Safety
Severe adverse events (death, life-threatening situations, hospitalizations or persistent disability) · 12 months
P = 0.044
Original publication
Discordance between left atrial pressure and risk scores in assessment of heart failure with preserved ejection fraction in patients with atrial fibrillation undergoing catheter ablation. Europace. Published 9 October 2025. doi:10.1093/europace/euaf245
Summarised from the published abstract; every number is checked against it