Heart failure & cardiomyopathies
Disease Progression in Exercise-Induced Arrhythmogenic Cardiomyopathy Compared With Arrhythmogenic Right Ventricular Cardiomyopathy
Authors' conclusion
RV structure and function deteriorated in ARVC patients but remained stable in EiAC patients during follow-up. The incidence of VA was high in both populations.
Study context
- Population
- Exercise-induced arrhythmogenic cardiomyopathy vs genotype-positive arrhythmogenic right ventricular (RV) cardiomyopathy730 echocardiographic examinations
- Participants
- 41 vs 125
- Exposure
- Exercise-induced arrhythmogenic cardiomyopathy (EiAC) vs arrhythmogenic right ventricular cardiomyopathy (ARVC)
- EiACn = 41
- ARVCn = 125reference
- Outcome
- Structural, functional and arrhythmic disease progression (repeated echocardiography and incident VA)
- Follow-up
- Long-term
Methodological detailsMedian follow-up 96 months (Q1-Q3: 73-132) ARVC and 82 months (Q1-Q3: 50-118) EiAC
- Median follow-up 96 months (Q1-Q3: 73-132) ARVC and 82 months (Q1-Q3: 50-118) EiAC
Main finding
As reported in the abstract
RV structure and function
- RV structure and function remained stable in EiAC, deteriorated in ARVC during follow-up
Observational data: associations, not effects.
Further findings
5-year and 10-year cumulative incidence of ventricular arrhythmias (VA)
- Similar between EiAC and ARVC
Original publication
Disease Progression in Exercise-Induced Arrhythmogenic Cardiomyopathy Compared With Arrhythmogenic Right Ventricular Cardiomyopathy. JACC Cardiovasc Imaging. Published 9 July 2025. doi:10.
Summarised from the published abstract; every number is checked against it