Distal versus conventional radial large-bore access for percutaneous coronary intervention of complex coronary lesions: Rationale and design of the DISCO COMPLEX randomized superiority trial
Study context
- Population
- Patients undergoing percutaneous coronary intervention (PCI) for complex coronary lesions (chronic total occlusions, left main disease, heavily calcified lesions, or complex bifurcations) with a 7-Fr guide catheterplanned
- Participants
- 708 patients
- Planned comparison
- Distal radial access (DRA) vs transradial access (TRA)
- Primary endpoint
- Forearm radial artery occlusion (RAO) by Doppler ultrasound
- Follow-up
- Hospital discharge
Methodological detailsrationale and design, investigator-initiated, prospective, multicentre, international, open-label, blinded outcome assessment, superiority, 1:1, prespecified noninferiority hand function substudy (DISCOPHILE COMPLEX), Recruitment from 10 to 15 centres across Europe; first patient enrolled August 31, 2023
- Rationale and design
- Investigator-initiated
- Prospective
- Multicentre
- International
- Open-label
- Blinded outcome assessment
- Superiority
- 1:1
- Prespecified noninferiority hand function substudy (DISCOPHILE COMPLEX)
- Recruitment from 10 to 15 centres across Europe; first patient enrolled August 31, 2023
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Distal versus conventional radial large-bore access for percutaneous coronary intervention of complex coronary lesions: Rationale and design of the DISCO COMPLEX randomized superiority trial. Am Heart J. Published 18 October 2025. doi:10.
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