Heart failure & cardiomyopathiesCross-sectional study
Distinct Blood Volume and Left Ventricular Adaptation to Severe Obesity in Middle-Aged Adults at Risk for Heart Failure
- Cross-sectional study
Authors' conclusion
While lean mass is the primary determinant of BV, fat mass is independently associated with BV expansion and larger LVEDV.
Study context
- Population
- Middle-aged (40–64 years) adults at increased risk for heart failure (HF) (elevated cardiac biomarkers plus established risk factors) and non-obese controls126 increased risk (IR) adults
- Participants
- 96 / 28 / 39 / 59
- Exposure
- At-risk adults by BMI class vs non-obese controls
- Controls (CON)n = 96reference
- IRNon-Obesen = 28
- IRClass-In = 39
- IRClass-II/IIIn = 59
Main finding
As reported in the abstract
Blood volume
CON
5046
mean · SD 1123 · ml
IRNon-Obese
5622
mean · SD 1137 · mL
IRClass-I
6033
mean · SD 1237 · mL
IRClass-II/III
6548
mean · SD 1153 · mL
- Fat mass independently associated with blood volume (BV) (β)
- 0.17, p < 0.001
- BV independently associated with LV end-diastolic volume (LVEDV) index (β)
- 0.54, p < 0.001
- BV lower in CON than all IR groups
- all p < 0.05
Observational data: associations, not effects.
Further findings
Mean, ml/kg fat-free mass
| Outcome | CON | IRNon-Obese | IRClass-I | IRClass-II/III | P value |
|---|---|---|---|---|---|
| Erythrocyte volume normalised to fat-free mass · greater erythrocyte volume (unnormalised p < 0.005) | 36.2 (SD 4.6) | Not reported in the abstract | Not reported in the abstract | 39.9 (SD 5.1) | P < 0.001 |
LVEDV indexed to body surface area
- Only IRClass-II/III had enlarged LVEDV index vs both CON and IRNon-Obese
- both, p < 0.05
Original publication
Distinct Blood Volume and Left Ventricular Adaptation to Severe Obesity in Middle-Aged Adults at Risk for Heart Failure. Eur J Heart Fail. Published 9 September 2025. doi:10.1002/ejhf.70037
Summarised from the published abstract; every number is checked against it