Arrhythmias & electrophysiologyCohort study
Distinct patterns of ventricular fibrillation onset in primary electrical diseases: insights from a retrospective multicentre registry
- Retrospective cohort study
- multicentre registry
Authors' conclusion
Primary electrical diseases display distinct VF patterns.
Study context
- Population
- Consecutive patients with Long QT syndrome (LQTS), catecholaminergic polymorphic ventricular tachycardia (CPVT), Brugada syndrome (BS) or idiopathic ventricular fibrillation (IVF) with recurrent ventricular fibrillation (VF) episodes76 VF episodes in 30 patients
- Participants
- 2,399 patients
- Exposure
- VF onset patterns across LQTS, CPVT, Brugada syndrome and idiopathic VF
- LQTSn = 1,587
- CPVTn = 155
- BSn = 584
- IVFn = 62
Main finding
As reported in the abstract
VF onset features (sinus rhythm before VF, trigger coupling interval, VF cycle length)
- CPVT: higher heart rate preceding VF, CL (mean ± SD, ms)
- 359 ± 26 ms; P < 0.001
- CPVT: shorter trigger CI initiating VF (ms)
- 256 ± 21 ms; P < 0.001
- Short-long-short sequence initiating VF, mostly in LQTS
- 54%; P < 0.001
- Very long trigger CI (>450 ms), mostly in LQTS
- 68%
- CPVT: shorter VF cycle length (ms)
- 168 ± 15 ms; P < 0.001
Observational data: associations, not effects.
Original publication
Distinct patterns of ventricular fibrillation onset in primary electrical diseases: insights from a retrospective multicentre registry. Europace. Published 30 September 2025. doi:10.1093/europace/euaf209
Summarised from the published abstract; every number is checked against it