Heart failure & cardiomyopathiesCross-sectional study
Distinguishing Heart Failure with Reduced Ejection Fraction from Heart Failure with Preserved Ejection Fraction: A Phenomics Approach
- Cross-sectional study
- subcohort of the prospective SHOP cohort
- age- and sex-matched controls
Authors' conclusion
We identified pathophysiological mechanisms related to increased cardiac wall thickness parameters and potentially druggable inflammatory markers from the TNFRSF in HFpEF.
Study context
- Population
- Patients with HF and controls without HF from the Singapore Heart Failure Outcomes and Phenotypes (SHOP) cohort; median age 65 years, 50% women
- Participants
- 217 / 213 / 216
- Exposure
- HFrEF vs HFpEF vs controls without HF
- HFrEFn = 217
- HFpEFn = 213
- Controlsn = 216reference
Main finding
As reported in the abstract
Discrimination from controls by protein profiles (92 biomarkers)
| Group | AUC |
|---|---|
| HFrEF | 0.89 |
| HFpEF | 0.94 |
Observational data: associations, not effects.
Original publication
Distinguishing Heart Failure with Reduced Ejection Fraction from Heart Failure with Preserved Ejection Fraction: A Phenomics Approach. Eur J Heart Fail. Published 4 February 2024. doi:10.1002/ejhf.3156
Summarised from the published abstract; every number is checked against it