Heart failure & cardiomyopathiesCohort study
Distinguishing left ventricular hypertrophy from hypertrophic cardiomyopathy in adolescents: a longitudinal observation study
- Longitudinal observational study
- age- and sex-matched
Authors' conclusion
Left ventricular hypertrophy was found in a similar proportion in early adolescence but progressed only in HCM genotype-positive patients.
Study context
- Population
- Early adolescent athletes and hypertrophic cardiomyopathy (HCM) genotype-positive patients
- Participants
- 76 vs 55
- Exposure
- Adolescent athletes vs HCM genotype-positive patients
- Athletesn = 76reference
- HCM genotype-positiven = 55
Main finding
As reported in the abstract
LV hypertrophy at baseline · baseline
P = 0.42
Observational data: associations, not effects.
Further findings
| Outcome | Athletes | HCM genotype-positive | P value |
|---|---|---|---|
| Septum thickness Z-score (ZIVSd) · baseline | 1.4 ± 0.9 | 1.0 ± 1.3 | P = 0.08 |
| progression rate | −0.17 (SE 0.05), P = 0.002 | 0.30 (SE 0.10), P = 0.001 | |
| LV volume Z-score (ZLVEDV) | 1.0 ± 0.6 | −0.1 ± 0.8 | P < 0.001 |
| progression rate | −0.05 (SE 0.04), P = 0.21 | −0.06 (SE 0.04), P = 0.12 |
Septum thickness Z-score (ZIVSd) · baseline
- Increased only in HCM genotype-positive
Safety
| Outcome | Athletes | HCM genotype-positive |
|---|---|---|
| Cardiac arrest | Not reported in the abstract | 2 events |
- Cardiac arrest: ages 13 and 14, ZIVSd 8.2-11.5
Original publication
Distinguishing left ventricular hypertrophy from hypertrophic cardiomyopathy in adolescents: a longitudinal observation study. Eur J Prev Cardiol. Published 22 November 2023. doi:10.1093/eurjpc/zwad361
Summarised from the published abstract; every number is checked against it