Arrhythmias & electrophysiology
Disturbed atrial metabolism, shear stress, and cardiac load contribute to atrial fibrillation after ablation: AXAFA biomolecule study
Authors' conclusion
Elevated concentrations of ANGPT2, BMP10, and NT-proBNP are associated with recurrent AF after a first AF ablation, suggesting that processes linked to disturbed cardiomyocyte metabolism, altered atrial shear stress, and increased load contribute to AF after AF ablation in patients.
Study context
- Population
- Patients undergoing a first atrial fibrillation (AF) ablation (64 years [58, 70]; 33% women)
- Participants
- 433 patients
- Comparison
- Baseline circulating biomolecule concentrations, recurrent AF vs no recurrence
- Recurrent AFn = 120
- Primary endpoint
- Recurrent AF
- Follow-up
- First 3 months after AF ablation
Methodological detailsbiomolecule study, 12 circulating biomolecules quantified in plasma before first AF ablation; Cox regression
- Biomolecule study
- 12 circulating biomolecules quantified in plasma before first AF ablation; Cox regression
Primary result
As reported in the abstract
Recurrent AF, adjusted for 11 clinical features and randomized treatment
Hazard ratio (95% CI)
Elevated NT-proBNP
1.58(1.29–1.94)
Elevated ANGPT2
1.37(1.12–1.67)
Elevated BMP10
1.24(1.02–1.51)
Further findings
Change in biomolecule concentrations
- ANGPT2, BMP10 and NT-proBNP decreased in arrhythmia-free patients but not in patients with recurrent AF
- Other eight biomarkers unchanged
Original publication
Disturbed atrial metabolism, shear stress, and cardiac load contribute to atrial fibrillation after ablation: AXAFA biomolecule study. Europace. Published 24 January 2024. doi:10.
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