Acute cardiac care & resuscitation
Does cardiopulmonary resuscitation before donor death affect solid organ transplant function? A systematic review and meta-analysis
Authors' conclusion
Organs transplanted from donors who received CPR demonstrated comparable outcomes at the longest follow-up compared to organs from donors who did not receive CPR. Kidneys and livers after uncontrolled donation after circulatory death showed worse outcomes compared to donation after brain death.
Study context
- Population
- Solid organ transplants from donors who underwent cardiopulmonary resuscitation (CPR) vs donors who did not receive CPRdonors, 33 studies (26 in adults)
- Participants
- 72,994 participants
- Comparison
- Solid organs transplanted from donors who underwent CPR compared to organs from donors who did not receive CPR
- Outcome
- graft survival at the longest follow-up
- Follow-up
- Longest
Pooled result
As reported in the abstract
Odds ratio (CI)
Donation after uncontrolled circulatory deathvs donation after brain deathlivers; lower long-term survival
0.51(0.32–0.83)
Donation after uncontrolled circulatory deathvs donation after brain deathkidneys; long-term survival not lower
0.64(0.36–1.15)
Donation in controlled circulatory deathvs uncontrolled circulatory deathkidneys; two studies; no different long-term survival
0.73(0.27–1.99)
Further pooled results
Short-term graft survival, kidneys
- Lower short-term survival for kidneys after donation after uncontrolled circulatory death vs donation after brain death
Original publication
Does cardiopulmonary resuscitation before donor death affect solid organ transplant function? A systematic review and meta-analysis. Resuscitation. Published 21 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →