Heart failure & cardiomyopathies
Does targeted positioning of the left ventricular pacing lead towards the latest local electrical activation in cardiac resynchronization therapy reduce the incidence of death or hospitalization for heart failure?
Study context
- Population
- Patients referred for de novo cardiac resynchronization therapy (CRT) implantation or upgrade to CRT from right ventricular pacingplanned
- Participants
- 1,000 patients
- Planned comparison
- Mapping-guided left ventricular (LV) lead positioning to latest local electrical activation vs conventional LV lead positioning in CRT
- Primary endpoint
- Composite of:
- Death
- Nonplanned heart failure (HF) hospitalization
- Follow-up
- Minimum 2 years and until 264 primary endpoints
Methodological detailstrial design paper; no results, national, double-blind, 1:1 randomisation, ITT, Enrollment began March 2018; expected complete by mid-2024
- Trial design paper; no results
- National
- Double-blind
- 1:1 randomisation
- ITT
- Enrollment began March 2018; expected complete by mid-2024
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Does targeted positioning of the left ventricular pacing lead towards the latest local electrical activation in cardiac resynchronization therapy reduce the incidence of death or hospitalization for heart failure? Am Heart J. Published 21 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →