Arrhythmias & electrophysiologyRandomised controlled trial
Dual-energy lattice-tip ablation system for persistent atrial fibrillation: a randomized trial
- Randomised controlled trial
- single-blind
- non-inferiority
Authors' conclusion
These results demonstrate non-inferior safety and effectiveness of the dual-energy catheter for the treatment of persistent AF.
Study context
- Population
- Patients with persistent atrial fibrillation (AF) undergoing catheter ablation
- Participants
- 420 patients
- Comparison
- Investigational vs Control
- Primary endpoint
- Composite effectiveness:
- Freedom from acute procedural failure
- Repeat ablation
- Arrhythmia recurrence
- Drug initiation or escalation or cardioversion after 3-month blanking
- Follow-up
- 1 year
Primary result
As reported in the abstract
P < 0.0001
Further findings
| Outcome | P value |
|---|---|
| Procedural times · shorter with investigational | P < 0.0001 |
Procedural times
- Procedural times shorter in investigational arm
Safety
events
| Outcome | Investigational | Control | P value |
|---|---|---|---|
| Major procedural or device-related complications (primary safety endpoint) · non-inferiority · non-inferiority met | 3 | 2 | P < 0.0001 |
Original publication
Dual-energy lattice-tip ablation system for persistent atrial fibrillation: a randomized trial. Nat Med. Published 17 May 2024. doi:10.1038/s41591-024-03022-6
Summarised from the published abstract; every number is checked against it