Heart failure & cardiomyopathiesCohort study
Dynamic Evolution of Tricuspid Regurgitation During Hospitalization in Patients with Acute Decompensated Heart Failure
- Retrospective cohort study
Authors' conclusion
Among ADHF patients with moderate-severe TR at admission, 49% had an in-hospital improvement in TR severity, which was associated with a reduction in risk of 5-year all-cause mortality and morbidity outcomes.
Study context
- Population
- Patients admitted for acute decompensated heart failure (ADHF) with ≥2 in-hospital echocardiographic evaluations of tricuspid regurgitation (TR)318 (30%) moderate-severe TR at admission
- Participants
- 1,054 patients
- Exposure
- In-hospital TR evolution: improved TR vs persistent moderate-severe TR vs persistent trivial-mild TR
- Outcome
- Composite of:
- All-cause mortality
- HF hospitalization
- Follow-up
- 5 years
Main finding
As reported in the abstract
5-year all-cause mortality/heart failure hospitalization (HFH)
- Improved TR vs Persistent moderate-severe TR · adjusted
- HR 0.524; P = 0.008
- Improved TR vs Persistent trivial-mild TR · adjusted; no different
- HR 0.878; P = 0.575
Observational data: associations, not effects.
Further findings
TR improvement among patients with moderate-severe TR at admission · in-hospital
- Improved TR severity
- 49%
Predictors of lower probability of improved TR
- AF, previous HF and higher pre-admission loop diuretic dosage associated with lower probability of improved TR
Subgroups by in-hospital variation of mitral regurgitation
- Results consistent across all subgroups
Original publication
Dynamic Evolution of Tricuspid Regurgitation During Hospitalization in Patients with Acute Decompensated Heart Failure. Eur J Heart Fail. Published 27 August 2024. doi:10.1002/ejhf.3433
Summarised from the published abstract; every number is checked against it