Valvular & structural heart diseaseMeta-analysis
Early and late transcatheter aortic valve implantation outcomes in aortic stenosis with transthyretin cardiac amyloidosis: a systematic review
- Systematic review of observational studies
Study context
- Population
- Elderly patients with severe aortic stenosis (AS) referred to transcatheter aortic valve implantation (TAVI)11 observational studies
- Participants
- 1,637 vs 644,107
- Comparison
- TAVI outcomes in AS+ATTR-CA vs isolated AS
- AS+ATTR-CAn = 1,637
- Isolated ASn = 644,107reference
Pooled result
As reported in the abstract
30-day mortality, stroke, major bleeding, AKI, permanent pacemaker implantation, HF readmission and late all-cause mortality after TAVI
- 30-day mortality low and similar between groups
- No consistent differences in stroke or major bleeding
- AKI and permanent pacemaker implantation more frequent in AS+ATTR-CA
- Higher HF readmissions and late all-cause mortality in AS+ATTR-CA during follow-up
Safety
AKI and permanent pacemaker implantation
- More frequent in AS+ATTR-CA
Original publication
Early and late transcatheter aortic valve implantation outcomes in aortic stenosis with transthyretin cardiac amyloidosis: a systematic review. Eur J Heart Fail. Published 3 September 2026. doi:10.1093/ejhf/xuag285
Summarised from the published abstract; every number is checked against it