Acute cardiac care & resuscitation
Early extracorporeal cardiopulmonary resuscitation (CPR) for refractory out-of-hospital cardiac arrest – A pre-planned per-protocol analysis of the INCEPTION-trial
Primary resultResult — go to the resultAdjusted odds ratio 1.9 95% CI 0.4–9.3Authors' conclusion
A pre-planned, pre-specified per-protocol analysis of the INCEPTION-trial, found a higher survival with favorable neurological in patients undergoing ECPR versus CCPR for refractory shockable OHCA. This difference did not reach statistical significance, but results should be interpreted with care, in the light of the small remaining sample size.
Study context
- Population
- Refractory out-of-hospital cardiac arrest (OHCA); per-protocol excluding criteria violations (incl. time-to-cannulation >60 minutes, ROSC before hospital arrival) and crossoversper-protocol
- Participants
- 81 participants
- Comparison
- Extracorporeal CPR vs conventional CPR
- Extracorporeal CPRn = 33
- Conventional CPRn = 48reference
- Primary endpoint
- Survival in a neurologically favorable condition (CPC 1-2)
- Follow-up
- 30 days
Methodological detailspre-specified per-protocol analysis, Bayesian analysis (minimally informative prior)
- Pre-specified per-protocol analysis
- Bayesian analysis (minimally informative prior)
Primary result
As reported in the abstract
Adjusted odds ratio
1.9
95% CI 0.4–9.3
p-value 0.393
By group
Extracorporeal CPR vs Conventional CPR
adjusted OR 1.9 (95% CI 0.4–9.3); p-value 0.393
- Bayesian posterior probability of any ECPR benefit
- 84%
- Bayesian posterior probability of a 5% absolute risk reduction
- 61%
Original publication
Early extracorporeal CPR for refractory out-of-hospital cardiac arrest – A pre-planned per-protocol analysis of the INCEPTION-trial. Resuscitation. Published 3 November 2023. doi:10.
Summarised from the published abstract; every number is checked against it