Acute cardiac care & resuscitation
Early left ventricular unloading after venoarterial extracorporeal membrane oxygenation: 1-year outcomes of the EARLY-UNLOAD randomized clinical trial
Primary result · All-cause deathResult — go to the resultHazard ratio 0.97 95% CI 0.60–1.58Authors' conclusion
Among patients with CS undergoing VA-ECMO, early routine LV unloading did not improve clinical outcomes at 1 year of follow-up.
Study context
- Population
- Patients with cardiogenic shock (CS) undergoing venoarterial extracorporeal membrane oxygenation (VA-ECMO)114 of 116 patients (98.3%) available for analysis at 1 year
- Participants
- 116 patients
- Comparison
- Early routine left ventricular (LV) unloading vs conventional approach
- early groupn = 58
- conventional groupn = 56reference
Primary result
All-cause death · 1 year
Hazard ratio
0.97
95% CI 0.60–1.58
P = 0.887
Events by treatment group
Early group vs conventional group
HR 0.97 (95% CI 0.60–1.58); P = 0.887
As reported in the abstract
Secondary outcomes
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Rehospitalization for HF, among 61 survivors at 30 days · 1 year · among 61 survivors at 30 days | 1.17 (0.43–3.24) | P = 0.758 | |
| Composite of all-cause mortality or rehospitalization for HF · 1 year | 1.01 (0.69–1.76) | P = 0.692 | |
| 0.20.5125Hazard ratio (log scale) |
Cardiac or non-cardiac mortality · 1 year
- No significant difference in cardiac or non-cardiac mortality
Follow-up completeness · 1 year
- Data available for analysis
- 114 of 116 patients (98.3%)
Original publication
Early left ventricular unloading after venoarterial extracorporeal membrane oxygenation: 1-year outcomes of the EARLY-UNLOAD randomized clinical trial. Eur Heart J Acute Cardiovasc Care. Published 3 January 2025. doi:10.
Summarised from the published abstract; every number is checked against it