Congenital heart diseaseCohort study
Early outcomes of children with univentricular circulation undergoing Fontan surgery: the EuroFontan registry
- Retrospective cohort study
- multicentre
- registry
- 21 centres across Europe
Authors' conclusion
Fontan surgery has evolved and, in contemporary practice, has low peri-operative morbidity and mortality. Morphology other than tricuspid atresia was associated with increased risk of early adverse outcomes
Study context
- Population
- Children with univentricular circulation undergoing Fontan completion, 2075 from the most recent 15-year period (Fontan surgery Jan 1990–Jan 2023)2,075 analysed (past 15 years)
- Participants
- 3,510 children
- Outcome
- Composite early adverse outcome:
- Death within 30 days or in-hospital
- Low cardiac output syndrome
- Stroke
- Fontan takedown
Main finding
As reported in the abstract
Composite early adverse outcome
Composite adverse outcome, 95% CI 4.2%-6.1%
5.1%
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Predictor of composite outcome: morphology other than tricuspid atresia (multivariable) · only significant predictor | 2.2 (1.21–3.99) | P = 0.01 | |
| 0.20.5125Odds ratio (log scale) |
- Predictor of composite outcome: morphology other than tricuspid atresia (multivariable): multivariable mixed-effects logistic regression, centre as random effect
Early mortality
- Early mortality, 95% CI .66%-1.54%
- 1.0%
Age at Fontan completion
- Median age at Fontan completion, IQR 3.2-6.2 years
- 4.2
Original publication
Early outcomes of children with univentricular circulation undergoing Fontan surgery: the EuroFontan registry. Eur Heart J. Published 23 October 2025. doi:10.1093/eurheartj/ehaf835
Summarised from the published abstract; every number is checked against it