Acute cardiac care & resuscitationCohort study
Early Post-ROSC Laboratory Phenotypes and Clinical Outcomes after Out-of-Hospital Cardiac Arrest: A 10-Year National Cohort Study
- retrospective cohort study
- unsupervised latent class analysis
- split-sample validation
- national databases
Authors' conclusion
Early post-ROSC laboratory data identified three prognostically distinct phenotypes among resuscitated OHCA patients. These exploratory findings support external validation and investigation of phenotype-guided therapies.
Study context
- Population
- Adult resuscitated OHCA patients of presumed cardiac etiology in Singapore, 2011–2022
- Participants
- 1,514 eligible patients
- Exposure
- Homeostatic (HOM) and immune-dysregulated (IMD) phenotypes compared to multi-organ dysfunction (MOD)
- MODn = 286reference
- HOMn = 967
- IMDn = 261
Main finding
As reported in the abstract
Poor neurological recovery · hospital discharge
Each group vs MODAdjusted odds ratio (95% CI)P value
HOM
0.50(0.30–0.78)
P = 0.004IMD
0.46(0.26–0.78)
P = 0.005Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | P value | |
|---|---|---|---|
| 30-day mortality · 30 days — HOM vs MOD | 0.71 (0.61–0.83) | P ≤ 0.01 | |
| 30-day mortality · 30 days — IMD vs MOD | 0.78 (0.64–0.94) | P ≤ 0.01 | |
| 3-year mortality · 3 years — HOM vs MOD | 0.70 (0.60–0.82) | P ≤ 0.01 | |
| 3-year mortality · 3 years — IMD vs MOD | 0.74 (0.62–0.90) | P ≤ 0.01 | |
| 0.512Adjusted hazard ratio (log scale) |
Phenotype reproducibility
- derivation entropy
- 0.817
- replication entropy
- 0.892
- Most discriminative variables: creatinine, eosinophil and lymphocyte
Original publication
Early Post-ROSC Laboratory Phenotypes and Clinical Outcomes after Out-of-Hospital Cardiac Arrest: A 10-Year National Cohort Study. Resuscitation. Published 9 October 2026. doi:10.1016/j.resuscitation.2026.111351
Summarised from the published abstract; every number is checked against it