Cardio-oncology & otherResearch article
Early Pregnancy Blood Pressure Trajectory Groups Predict Hypertensive Disorders of Pregnancy
- retrospectively identify patients with a singleton delivery
- Electronic health record data
- large urban academic center
- Multivariable logistic regression
- C-statistics
Authors' conclusion
BP trajectories, based on early pregnancy BP measurements, improved ability to predict HDP diagnosis in diverse pregnant cohorts. BP trajectories may improve identification of high-risk patients for more intensive BP monitoring during pregnancy.
Study context
- Population
- Patients with a singleton delivery from 2012 to 2020 in a large urban academic center, excluding those with pre-existing hypertension or serious medical conditions
- Participants
- 25,879 patients
- Comparison
- Inclusion of trajectories into predictive models compared to clinical risk factors alone
- Outcome
- HDP diagnosis, including preeclampsia and gestational hypertension
Main finding
As reported in the abstract
diagnosed with hypertensive disorders of pregnancy (HDP)
5,694 (21.9%)
adjusted odds of HDP diagnosis across trajectories, lowest
1.6 (95% CI: 1.4-1.8)
adjusted odds of HDP diagnosis across trajectories, highest
6 (95% CI: 5.3-6.9)
Further findings
C-statistic
| Outcome | Models including trajectories | Clinical risk factors alone |
|---|---|---|
| Predictive model discrimination (C-statistic) | 0.71 (95% CI 0.70–0.72) | 0.66 (95% CI 0.65–0.67) |
Original publication
Early Pregnancy Blood Pressure Trajectory Groups Predict Hypertensive Disorders of Pregnancy. JACC Adv. Published 13 June 2026. doi:10.1016/j.jacadv.2026.102912
Summarised from the published abstract; every number is checked against it