Arrhythmias & electrophysiologySecondary analysis
Early recurrence of atrial tachyarrhythmia after catheter ablation and its associations with clinical outcomes, atrial fibrillation burden, and blanking period duration: a post hoc analysis of the CABANA trial
- Secondary analysis of the CABANA randomised trial
- post hoc analysis
Authors' conclusion
ERAT was associated with higher risks of cardiovascular hospitalization and late atrial tachyarrhythmia recurrence in a time-dependent manner, supporting a shorter blanking period to better identify patients at risk of adverse rhythm outcomes.
Study context
- Population
- Patients from the CABANA trial who underwent catheter ablation with trial-specific ECG monitoring data
- Participants
- 811 patients
- Comparison
- Early recurrence of atrial tachyarrhythmia (ERAT) vs no ERAT after catheter ablation for atrial fibrillation (AF)
- ERATn = 567
- Primary endpoint
- Composite of:
- All-cause mortality
- Disabling stroke
- Serious bleeding
- Cardiac arrest
- Follow-up
- Median 4 years (IQR 2.5-5.2)
Primary result
As reported in the abstract
Primary composite outcome
- ERAT: no increased risk of the primary composite outcome
Secondary outcomes
| Outcome | aHR (95% CI) | |
|---|---|---|
| CV hospitalization | 1.35 (1.07–1.71) | |
| All-cause mortality or CV hospitalization | 1.33 (1.07–1.66) | |
| Late atrial tachyarrhythmia recurrence | 1.35 (1.07–1.71) | |
| Late atrial tachyarrhythmia recurrence · ERAT between 60 and 90 days after ablation | 1.80 (1.16–2.79) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
- ERAT incidence
- 69.9% · 567 of 567
- Late atrial tachyarrhythmia recurrence — ROC optimal threshold for predicting late recurrence: 58 days
- AUC 0.727
Original publication
Early recurrence of atrial tachyarrhythmia after catheter ablation and its associations with clinical outcomes, atrial fibrillation burden, and blanking period duration: a post hoc analysis of the CABANA trial. Europace. Published 7 July 2026. doi:10.1093/europace/euag173
Summarised from the published abstract; every number is checked against it