Arrhythmias & electrophysiologyCohort study
Early U.S. Experience With Catheter Ablation of Ventricular Arrhythmias With a Dual-Energy Lattice-Tip Catheter
- prospectively maintained registry of consecutive patients
Authors' conclusion
In this first U.S. series, catheter ablation of VAs with a lattice-tip RFA/PFA catheter appeared effective and generally safe. Caution should be exercised when applying PFA in proximity to exposed conductors of implantable cardiac devices.
Study context
- Population
- Patients undergoing catheter ablation of VA with an radiofrequency ablation (RFA)/pulsed field ablation (PFA) lattice-tip catheter (Sphere-9; Medtronic) between January and September 2025patients who underwent ablation of VA using the lattice-tip catheter · scar-related ventricular tachycardia (VT) 50 · frequent premature ventricular contractions (PVCs) 9
- Participants
- 59 patients
- Exposure
- scar-related VT vs frequent PVCs
- scar-related VTn = 50
- frequent PVCsn = 9
Main finding
As reported in the abstract
Acute procedural success (non-inducibility of any VT, excluding nonclinical VTs with cycle length ≤240 milliseconds, or complete PVC suppression)
Observational data: associations, not effects.
Further findings
VT recurrence; death/heart transplantation/left ventricular assist device implantation · median follow-up of 100 days (Q1-Q3: 51-172 days)
patients
- VT recurred
- 9 (18%)
- death/heart transplantation/left ventricular assist device implantation
- 6 (12%)
VT-free survival and VT recurrence · 6 months
- Kaplan-Meier-estimated VT-free survival
- 69.8% (95% CI: 54.0%-90.3%)
- Fine-Gray cumulative incidence of VT recurrence, accounting for competing risks
- 28.4% (95% CI: 11.0%-45.8%)
PVC recurrence · median follow-up of 54 days (Q1-Q3: 40-71 days)
- No patient with PVCs had recurrence
Safety
Major procedure-related complications
- Major procedure-related complications
- Three
- major bleeding events
- 2
- implantable cardioverter-defibrillator system failure after PFA application approximately 7.5 mm from the tip of a left ventricular pacing lead (required intra-operative device generator change)
- 1
Original publication
Early U.S. Experience With Catheter Ablation of Ventricular Arrhythmias With a Dual-Energy Lattice-Tip Catheter. JACC Clin Electrophysiol. Published 26 April 2026. doi:10.1016/j.jacep.2026.03.002
Summarised from the published abstract; every number is checked against it