Heart failure & cardiomyopathiesCohort study
Early U.S. Heart Transplant Experience With Normothermic Regional Perfusion Following Donation After Circulatory Death
- Retrospective cohort study
- national registry (UNOS)
- propensity-matched analysis
Authors' conclusion
In this largest national series of DCD HT procurement perfusion strategies, NRP is associated with improved short-term survival as compared with DPP.
Study context
- Population
- Adult recipients and donors of controlled DCD heart transplantation, UNOS registry, January 2019-December 2023
- Participants
- 918 recipients
- Exposure
- Normothermic regional perfusion (NRP) vs direct procurement and perfusion (DPP) procurement in DCD heart transplantation
- NRPn = 296
- DPPn = 622reference
- Outcome
- Overall survival
Main finding
As reported in the abstract
Hazard ratio
0.39
95% CI 0.22–0.70
P = 0.002
NRP vs DPP
HR 0.39 (95% CI 0.22–0.70); P = 0.002
- Unadjusted Kaplan-Meier: improved short-term survival with NRP
- log-rank P = 0.005
- Propensity-matched analysis: cumulative survival benefit to NRP
- log-rank P = 0.006
Observational data: associations, not effects.
Original publication
Early U.S. Heart Transplant Experience With Normothermic Regional Perfusion Following Donation After Circulatory Death. JACC Heart Fail. Published 31 July 2024. doi:10.1016/j.jchf.2024.06.007
Summarised from the published abstract; every number is checked against it