Early Versus Delayed Invasive Management of Female Patients With Non–ST-Elevation Acute Coronary Syndrome: An Individual Patient Data Meta-Analysis
Pooled result · Composite of all-cause mortality or myocardial infarctionResult — go to the resultHazard ratio 0.79 95% CI 0.60–1.06Authors' conclusion
Early invasive management in female patients with non-ST-elevation acute coronary syndrome, compared with delayed invasive management, was not associated with a significant reduction in the hazard for the primary end point. In prespecified subgroup analysis, high-risk female patients as assessed with Global Registry of Acute Coronary Events score >140 or elevated cardiac biomarkers experienced significant reductions in all-cause mortality or myocardial infarction at 6 months following early invasive management.
Study context
- Population
- Female patients with non-ST-elevation acute coronary syndromefemale patients from six trials
- Participants
- 2,257 patients
- Comparison
- Early versus delayed timing of coronary angiography
- Early invasive groupn = 1,141
- Delayed invasive groupn = 1,116reference
- Outcome
- Composite of:
- All-cause mortality
- Myocardial infarction
- Follow-up
- 6 months
Methodological detailsrandom-effects Cox models, Randomized controlled trials
- Random-effects Cox models
- Randomized controlled trials
Pooled result
As reported in the abstract
Hazard ratio
0.79
95% CI 0.60–1.06
P = 0.12
Early invasive groupvs delayed invasive group
hazard ratio 0.79 (95% CI 0.60–1.06); P = 0.12
Further pooled results
| Outcome | Hazard ratio (95% CI) | P value | |
|---|---|---|---|
| Recurrent ischemia | 0.60 (0.39–0.94) | P = 0.025 | |
| All-cause mortality or myocardial infarction, high-risk female patients with Global Registry of Acute Coronary Events score >140 (prespecified subgroup) · 6 months | 0.65 (0.45–0.94) | P = 0.021 | |
| 0.20.5125Hazard ratio (log scale) |
- All-cause mortality or myocardial infarction, high-risk female patients with Global Registry of Acute Coronary Events score >140 (prespecified subgroup): P interaction =0.035
Female patients with elevated cardiac biomarkers (subgroup)
- Similar benefits were observed
Original publication
Early Versus Delayed Invasive Management of Female Patients With Non–ST-Elevation Acute Coronary Syndrome: An Individual Patient Data Meta-Analysis. Circ Cardiovasc Interv. Published 4 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →