Arrhythmias & electrophysiologySecondary analysis
Early versus late atrial fibrillation recurrence after pulsed field ablation: insights from the admIRE trial
- Secondary analysis of the admIRE trial
Authors' conclusion
This admIRE subanalysis demonstrated that PAF patients who experience ER after PFA are at a substantially higher risk for LR.
Study context
- Population
- Patients with symptomatic paroxysmal AF undergoing pulsed field ablation with ≥1 transtelephonic monitoring transmission during the blanking period
- Participants
- 169 patients
- Comparison
- Early recurrence vs no early recurrence after pulsed field ablation (PFA)
- Early recurrence (ER)n = 31
- No ERn = 138reference
- Primary endpoint
- Late recurrence (recurrence in the evaluation period, days 91-365) and freedom from documented recurrence by ER
- Follow-up
- 12 months
Primary result
As reported in the abstract
Late recurrence; 12-month freedom from documented recurrence
Adjusted hazard ratio
7.9
95% CI 4.1–15.1
P < 0.001
Events by treatment group
ER vs No ER
adjusted HR 7.9 (95% CI 4.1–15.1); P < 0.001
Further findings
Incidence of ER · days 1-90
- ER observed
- 20.1% (31/169)
- Time to first documented ER
- 49 (37-61) days
Late recurrence (LR) with ER onset within first 2 months (subgroup)
- LR
- 87.0% (20/23)
Original publication
Early versus late atrial fibrillation recurrence after pulsed field ablation: insights from the admIRE trial. Europace. Published 16 January 2025. doi:10.1093/europace/euaf007
Summarised from the published abstract; every number is checked against it