Randomized Study Comparing Angiography Guidance With Physiology Guidance After Prepercutaneous Coronary Intervention (PCI): The EASY-PREDICT Study
Authors' conclusion
In all-comers patients undergoing uncomplicated PCI, routine post-PCI physiology assessment was not associated with clinical benefit compared with standard angiographic guidance. Further study is required to determine how post-PCI physiology guidance can be helpful in selected lesions.
Study context
- Population
- All-comers patients referred for diagnostic angiography and possible PCI, randomized after uncomplicated PCIpatients randomized
- Participants
- 221 patients
- Comparison
- post-PCI physiology compared with standard angiographic guidance
- Angiography groupn = 110
- Physiology groupn = 111
- Primary endpoint
- Target vessel failure:
- Cardiac death
- Myocardial infarction
- Target vessel revascularization
- Follow-up
- 18 months post-PCI
Methodological detailsall-comers, high-volume tertiary care hospital
- All-comers
- High-volume tertiary care hospital
Primary result
As reported in the abstract
Further findings
Cardiac death · 18-month follow-up
Myocardial infarction · 18-month follow-up
Target vessel revascularization · 18-month follow-up
- Cardiac death: P =0.32
- Myocardial infarction: P =0.66
- Target vessel revascularization: P =0.24
Angina score, medication, quality of life
- No difference in angina score, medication, or quality of life
Immediate post-PCI physiology results deemed suboptimal (physiology group)
- Suboptimal cases, with further optimization steps
- 22 (17%)
Final post-PCI physiology results
- Resting distal coronary pressure to aortic pressure ratio
- 0.95±0.04
- Diastolic pressure ratio
- 0.94±0.06
- Fractional flow reserve
- 0.90±0.07
- Lesions remaining with fractional flow reserve values ≤0.80
- 9 lesions (7%)
Original publication
Randomized Study Comparing Angiography Guidance With Physiology Guidance After PCI: The EASY-PREDICT Study. Circ Cardiovasc Interv. Published 21 May 2025. doi:10.
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