Echocardiographic findings in cancer-associated non-bacterial thrombotic endocarditis: clinical series of 111 patients from a single institution
Authors' conclusion
Ca-NBTE manifests mainly as thrombotic mobile masses attached to thickened MV and AV, with distinct variations in size based on valve type. Embolic destination but not cancer type is associated with NBTE mass size and location.
Study context
- Population
- Patients with cancer-associated non-bacterial thrombotic endocarditis (Ca-NBTE), Mayo Clinic, 31 March 2002–30 June 2022
- Participants
- 111 patients
- Outcome
- Heart valve abnormalities on echocardiography and their relation to embolic complications and cancer types
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Mitral valve involvement
- 69
- Aortic valve involvement
- 56
- Tricuspid valve involvement
- 8
- Pulmonic valve involvement
- 1
- 2 valves involved
- 18
- Embolic complications
- n = 102, 91.9%
- Mitral valves (MV): upstream (atrial) vs downstream side
- 90% vs. 49.3%
- TV: downstream (ventricular) vs upstream side
- 75% vs. 37.5%
- NBTE size (cm), TV (largest)
- 0.63-2.40 × 0.39-1.77
- NBTE size (cm), MV; TV vs MV length P = 0.001, width P = 0.03
- 0.11-1.81 × 0.11-1.62
- NBTE size (cm), AV; TV vs AV length P = 0.001, width P = 0.056
- 0.20-2.70 × 0.11-1.51
- MV masses longer in systemic vs cerebral emboli (borderline)
- P = 0.057
- Thickened leaflets, MV
- 79.6%
- Thickened leaflets, AV
- 69.6%
- Closing margins affected (MV, AV, TV)
- 73.9% MV, 85.7% AV, and 62.5% of TV
- Commissures affected, MV
- 8.7%
- Commissures affected, AV
- 41.1%
- Severe regurgitation, MV
- 5
- Severe regurgitation, AV
- 5
Observational data: associations, not effects.
Original publication
Echocardiographic findings in cancer-associated non-bacterial thrombotic endocarditis: clinical series of 111 patients from a single institution. Eur Heart J Cardiovasc Imaging. Published 25 April 2024. doi:10.
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