Heart failure & cardiomyopathiesCohort study
Echocardiographic heart ageing patterns predict cardiovascular and non-cardiovascular events and reflect biological age: the SardiNIA study
- Prospective cohort study
Authors' conclusion
Standard Doppler echocardiography detects slow, normal, and accelerated heart ageing patterns. They predict CV and non-CV events, reflect biological age
Study context
- Population
- Healthy subjects (SardiNIA study)
- Participants
- 2,614 subjects
- Exposure
- Slow vs normal vs accelerated echocardiographic heart ageing patterns
- Outcome
- Fatal and non-fatal CV events
Main finding
As reported in the abstract
Kaplan-Meier curves diverged significantly; event rate lowest in slow, intermediate in normal, highest in accelerated
P = 0.0001
Heart ageing patterns predicted the primary endpoint in Cox model, independent of chronological age and risk factors
P = 0.01
Observational data: associations, not effects.
Secondary outcomes
Prevalence of heart ageing patterns
| Outcome | Slow | Normal | Accelerated |
|---|---|---|---|
| HeartPhAge vs chronological age | 9 years younger | overlapping | 4 years older |
- HeartPhAge vs chronological age: slow and accelerated both P < 0.0001
Composite of cardiovascular (CV) and non-CV events and all-cause death
- Kaplan-Meier curves diverged significantly
- P = 0.0001
- Heart ageing patterns predicted secondary endpoints in Cox model, independent of chronological age and risk factors
- P = 0.03 to <0.0001
Original publication
Echocardiographic heart ageing patterns predict cardiovascular and non-cardiovascular events and reflect biological age: the SardiNIA study. Eur J Prev Cardiol. Published 1 August 2023. doi:10.1093/eurjpc/zwad254
Summarised from the published abstract; every number is checked against it