Valvular & structural heart diseaseSecondary analysis
Echocardiographic Outcomes With Transcatheter Edge-to-Edge Repair for Degenerative Mitral Regurgitation in Prohibitive Surgical Risk Patients
- Secondary analysis of the CLASP IID randomised trial
- independent echocardiographic core laboratory
Authors' conclusion
Treatment with PASCAL and a smaller flail gap were significant factors in sustaining MR ≤1+ to 6 months.
Study context
- Population
- Patients at prohibitive surgical risk with significant symptomatic degenerative mitral regurgitation (MR)randomized
- Participants
- 180 patients
- Comparison
- PASCAL vs MitraClip for mitral transcatheter edge-to-edge repair (M-TEER)
- PASCALn = 117
- MitraClipn = 63reference
- Primary endpoint
- Echocardiographic outcomes and baseline variables associated with residual MR ≤1+
Primary result
Residual MR ≤1+
Adjusted odds ratio
2.72
95% CI 1.08–6.89
By group
PASCAL vs MitraClip
adjusted OR 2.72 (95% CI 1.08–6.89)
As reported in the abstract
- Smaller flail gap: MR ≤1+ at discharge, adjusted OR
- 0.70 (95% CI 0.50-0.99)
- Smaller flail gap: sustained MR ≤1+ to 6 months, adjusted OR
- 0.76 (95% CI 0.60-0.98)
Further findings
MR ≤2+ at discharge
- All patients achieved MR ≤2+ at discharge
Original publication
Echocardiographic Outcomes With Transcatheter Edge-to-Edge Repair for Degenerative Mitral Regurgitation in Prohibitive Surgical Risk Patients. JACC Cardiovasc Imaging. Published 13 December 2023. doi:10.1016/j.jcmg.2023.09.015
Summarised from the published abstract; every number is checked against it