Heart failure & cardiomyopathiesMeta-analysis
Echocardiographic Predictors of Cardiovascular Outcome in Heart Failure with Preserved Ejection Fraction
- Systematic review and meta-analysis
- random effects meta-analysis
Authors' conclusion
Impaired LV global longitudinal strain, lower LA reservoir strain and lower TAPSE/PASP ratio predict cardiovascular death and HF hospitalization in HFpEF and are independent of filling pressures, clinical characteristics and natriuretic peptides.
Study context
- Population
- Patients with HFpEF
- Participants
- 20,056 patients · 46 studies
- Outcome
- Composite of:
- CV death
- Heart failure (HF) hospitalization
Pooled result
As reported in the abstract
CV death and HF hospitalisation (composite primary endpoint)
Estimate (95% CI)
Decreased LV global longitudinal strain
HR 1.24 per 5% decrease(1.10–1.39)
Lower TAPSE/PASP ratio
HR 1.17 per 0.1 unit decrease(1.07–1.25)
Each row per its own increment, as printed
- Decreased left atrial (LA) reservoir strain
- HR 1.30 per 5% decrease
Further pooled results
Other independent predictors (less robust)
- Higher E/e', moderate to severe tricuspid regurgitation, left ventricular (LV) mass index and LA ejection fraction were also independent predictors, but less robust
Original publication
Echocardiographic Predictors of Cardiovascular Outcome in Heart Failure with Preserved Ejection Fraction. Eur J Heart Fail. Published 7 May 2024. doi:10.1002/ejhf.3271
Summarised from the published abstract; every number is checked against it