Heart failure & cardiomyopathiesCohort study
Echocardiographic risk stratification in heart failure with post-capillary pulmonary hypertension: prognostic value of left atrial volume index (LAVI) and TAPSE/PASP
- prospective multicentre cohort
- 13 French centres (2012-2018)
Authors' conclusion
LAVI and TAPSE/PASP are strong, non-invasive predictors of adverse outcomes in HF with pcPH and may enhance prognostic assessment beyond invasive haemodynamics and clinical scores.
Study context
- Population
- Adults with chronic heart failure (HF) and confirmed post-capillary pulmonary hypertension (pcPH) (mPAP > 20 mmHg and pulmonary arterial wedge pressure > 15 mmHg) undergoing right heart catheterization (RHC); patients with precapillary PH or severe pulmonary/renal comorbidities excluded
- Exposure
- prognostic utility of LAVI and TAPSE/PASP compared with invasive haemodynamic parameters
- Outcome
- Composite of:
- All-cause mortality
- Urgent heart transplantation or LVAD
- Unplanned HF hospitalization
- Follow-up
- 3 years
Main finding
As reported in the abstract
Hazard ratio
1.97
95% CI 1.41–2.75
P < 0.0001
composite echocardiographic risk criterion
HR 1.97 (95% CI 1.41–2.75); P < 0.0001
Observational data: associations, not effects.
Further findings
Primary outcome by HF phenotype (HFrEF, HFpEF)
- Results were consistent across HFrEF and HFpEF phenotypes
Multivariable model including the MAGGIC score
- Both the echocardiographic criterion and the clinical score remained independently associated with outcomes
Original publication
Echocardiographic risk stratification in heart failure with post-capillary pulmonary hypertension: prognostic value of LAVI and TAPSE/PASP. Eur Heart J Cardiovasc Imaging. Published 30 January 2026. doi:10.1093/ehjci/jeag034
Summarised from the published abstract; every number is checked against it